Ehlers-Danlos syndromes (EDS)
Developing diagnostics for EDS patients
About Our EDS Research
Ehlers-Danlos syndromes (EDS) are a group of inherited disorders that affect the body’s connective tissues, often leading to joint hypermobility, fragile skin, and delayed wound healing.
While some forms, such as classical EDS, can be diagnosed through genetic testing of collagen-related genes, the most common type - hypermobile EDS - still lacks a reliable genetic marker. As a result, many patients experience years of uncertainty before receiving a correct diagnosis.
In our lab, we focus on understanding how the nanoscale structure and mechanics of collagen—the body’s main structural protein—are altered in EDS. By combining advanced imaging and biomechanical measurements, we aim to identify unique “fingerprints” of collagen in affected skin. This research not only deepens scientific knowledge about how EDS disrupts tissue strength and function but also moves us closer to developing faster, more accurate diagnostic tools.
Ultimately, our goal is to help patients receive timely care and reduce the physical and emotional burden of living with EDS.
Recent Lab publication on EDS:
Neshatian, Mehrnoosh, et al. "Investigation of dermal collagen nanostructures in Ehlers-Danlos Syndrome (EDS) patients." Plos one 19.8 (2024): e0307442.
